 FT | FC København  | 2 - 0 |  Nordsjælland | |
 FT | Al Diriyah  | 0 - 2 |  Al-Qadisiyah FC | |
 FT | Lech Poznań  | 2 - 1 |  Jagiellonia Białystok | |
 FT | FC Basel 1893  | 1 - 2 |  Sion | |
FT | Lugano  | 1 - 0 |  Servette FC | |
 FT | Gent  | 1 - 0 |  OH Leuven | |
FT | Anderlecht  | 1 - 0 |  Kortrijk | |
 FT | Slask Wroclaw  | 2 - 1 |  Pogon Szczecin | |
 FT | Toulouse  | 0 - 1 |  LOSC Lille | |
 FT | Hibernian  | 1 - 3 |  Hearts | |
 FT | Cagliari  | 1 - 2 |  Hellas Verona | |
 FT | Real Sociedad  | 0 - 0 |  Celta de Vigo | |
 FT | Gremio  | 3 - 1 |  Internacional | |
 FT | Arema FC  | 4 - 0 |  Adhyaksa | |
 FT | Trường Tươi Đồng Nai  | 0 - 2 |  Thể Công-Viettel | |
FT | Bali United  | 2 - 1 |  PSS Sleman | |
| Abha  | vs |  Al-Ettifaq | |
 | SV Kapfenberg  | vs |  WSPG Wels | |
| SCR Altach  | vs |  Bischofshofen | |
| Wallern / Marienkirchen  | vs |  Ried | |
| Floridsdorfer AC  | vs |  Schwarz-Weiß Bregenz | |
 | İstanbul Başakşehir  | vs |  Galatasaray | |
| Viborg  | vs |  Lyngby | |
 | Fredrikstad  | vs |  Bodø / Glimt |