 FT | Philadelphia Union  | 4 - 2 |  Orlando City SC | |
FT | Atlanta United FC  | 2 - 2 |  New York City FC | |
FT | CF Montreal  | 3 - 1 |  FC Cincinnati | |
FT | Charlotte  | 0 - 1 |  Chicago Fire | |
FT | FC Dallas  | 1 - 0 |  Los Angeles FC | |
FT | Seattle Sounders  | 3 - 1 |  Minnesota United FC | |
FT | Nashville SC  | 2 - 0 |  Toronto FC | |
FT | Austin  | 3 - 3 |  San Diego | |
FT | Houston Dynamo  | 0 - 2 |  Sporting Kansas City | |
 FT | Mexico  | 1 - 1 |  Colombia | |
FT | Real Salt Lake  | 3 - 0 |  New England Revolution | |
 FT | Sint Maarten  | 0 - 1 |  Belize | |
FT | Los Angeles Galaxy  | 3 - 2 |  Colorado Rapids | |
FT | Vancouver Whitecaps  | 3 - 3 |  DC United | |
FT | San Jose Earthquakes  | 3 - 1 |  Portland Timbers | |
FT | Vanuatu  | 4 - 1 |  New Caledonia | |
 | Kaya  | vs |  Philippine Army | |
| Manila Digger  | vs |  Azkals | |
 | Gangwon FC  | vs |  Incheon United | |
 | Sporting Hortaleza  | vs | Guimar | |
| Cented Academy | vs | San José Soria | |
 | Bình Minh Sài Gòn  | vs | Thái Nguyên | |
 | Shaanxi Union  | vs |  Dalian Huayi | |
| Trung Quốc  | vs |  New Zealand | |
| Shanghai Shenhua  | vs |  Zenit | |
 | Real Valladolid  | vs |  Córdoba | |
| Stallion  | vs |  Maharlika | |
 | Lithuania  | vs |  Azerbaijan | |
 | Camacha  | vs |  Florgrade | |
 | Rochefort  | vs |  K. Lierse S.K. |